Alfonso Valencia

Beyond-COVID (BY-COVID) aims to provide comprehensive open data on SARS-CoV-2, and other infectious diseases across scientific, medical, public health and policy domains. The project will have a strong emphasis on mobilising raw viral sequences, helping to identify and monitor the spread of SARS-CoV-2 variants. It will further accelerate access to and linking of data and...

Cancer is the second leading cause of death in the EU. More than 150.000 persons within EU-28 die of colorectal cancer (CRC) every year (more than 10% of all cancer-related deaths). For advanced-stage disease, where surgery is not possible, systemic therapy is used. A few decades ago, chemotherapy was the only option, with overall survival around one year. With chemotherapy,...

The EXSCALATE4CoV (E4C) project aims to exploit the most powerful computing resources currently based in Europe to empowersmart in-silico drug design. Advanced Computer-Aided Drug Design (CADD) in combination with the high throughput biochemicaland phenotypic screening will allow the rapid evaluation of the simulations results and the reduction of time for the discovery ofnew...

Personalised Medicine (PerMed) opens unexplored frontiers to treat diseases at the individual level combining clinical and omics information. However, the performances of the current simulation software are still insufficient to tackle medical problems such as tumour evolution or patient-specific treatments. The challenge is to develop a sustainable roadmap to scale-up the...