- Status:
- Granted
- Publication number:
- WO2020/120576
- Priority date:
- Inventor:
- Lucia Diaz Bueno, Lorena Gonzalez Velasco, Ana Ignea Fernandez, Modesto Orozco Lopez, Ángel Rodriguez Nebreda, Daniel Soler Viladrich, Robert Soliva Soliva
- Applicant:
- Barcelona Supercomputing Center, Fundació Institut de Recerca Biomedica (IRB), Institucio Catalana de Recerca i Estudis Avançats (ICREA), Nostrum BioDiscovery S.L, Universitat de Barcelona
Abstract
The present invention concerns inhibitors of p38α autophosphorylation, pharmaceutical compositions comprising them, and their use in the treatment of a number of diseases, such as myocardial ischemia reperfusion injury. The inhibitors satisfy the following general formula: wherein R, R1, R2, R4, and R5 may have different meanings.