p38α Autophosphorylation Inhibitors

 Status:
Research & examination
 Publication number:
WO2020/120576
 Priority date:
 Inventor:
LUCIA DIAZ BUENO,  Lorena Gonzalez Velasco,  Ana Ignea Fernandez,  Modesto Orozco Lopez,  Ángel Rodriguez Nebreda,  Daniel Soler Viladrich,  Robert Soliva Soliva
 Applicant:
Barcelona Supercomputing Center, Fundació Institut de Recerca Biomedica (IRB), Institucio Catalana de Recerca i Estudis Avançats (ICREA), Nostrum BioDiscovery S.L, Universitat de Barcelona

Abstract

The present invention concerns inhibitors of p38α autophosphorylation, pharmaceutical compositions comprising them, and their use in the treatment of a number of diseases, such as myocardial ischemia reperfusion injury. The inhibitors satisfy the following general formula: wherein R, R1, R2, R4, and R5 may have different meanings.