Genetics of Complex Diseases

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A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. This project focused on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We...

Un dels grans reptes de la indústria farmacèutica és la medicina personalitzada. Difícilment una sola molècula esdevindrà un tractament farmacològic amb èxit per a tota la població mundial donada la gran variabilitat genètica natural en la població. Actualment l’elevat índex de...

A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal was to identify novel mitochondrial-dependent...

Despite tremendous investments to identify susceptibility genes for type 2 diabetes (T2D) through genome-wide association studies (GWAS), only around 10% of the variance attributable to genetic factors can be explained with the currently identified variants. In addition, each of the identified locus frequently maps to several genes, remaining a challenge to assign a causal...

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