Projects

Cardiovascular diseases remain the main cause of mortality worldwide; in particular, heart failure (HF) poses complex challenges in clinical practice, as it is associated with a significant variability in aetiologies, manifestations and risks, as well as in its progression andtrajectories over time. Clinical risks of HF can vary from reduced cardiac function and regular...

Nueve universidades y centros de investigación han puesto en marcha la Red Española de Investigación en Modelización Computacional Cardiaca. Bajo el acrónimo V-Heart SN, esta red pretende facilitar la utilización de corazones virtuales -modelos computacionales- en la práctica clínica diaria, lo que permitirá el...

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, accounting for about a third of annual deaths. Refusing structured and unstructured data has the potential for significant health benefits for the population suffering from CVD. Healthcare data reuse in Europe faces privacy and fragmentation issues, high data formats and language diversity, and a...

In the past decade, many scientific domains have been transformed into data-driven disciplines relying on the exchange and integration of internationally distributed data. Exploiting this data is still a laborious and largely manual task, prone to losses and errors, and increasingly specialised beyond most users technical capabilities. FAIR practices are encouraged but their...

As our planet heats up due to climate change, outbreaks of zoonotic diseases – diseases that spread from animals to humans – are increasing and expanding to new parts of the world, in particular Europe. Warmer temperatures, more variable rainfall, and the loss of biodiversity influence the survival and spread of zoonotic pathogens, and the reproduction and geographic location of...

High-fidelity simulations using supercomputers play a key role in aerospace and automotive design for reducing the number of ground and in-flight tests. The mesh lies at the heart of the simulation: it reproduces the geometry using elements that, for engineering applications, are required to be curved (high-order).

This project exploits geometric...

Modeling the heartbeat is a highly complex task that involves several scales and different tightly coupled problems. A large number of spatial orders of magnitude are linked, from the microscopic cell arrangement into a volumetric description, to the macroscopic shape of the cardiac chambers. In the same way, several temporal scales coexist, from...

CanSHare will develop the first centralised, secure and sustainable platform for enhanced cross-border data sharing and multi-cohort personalised medicine research in cardiology. At its heart, the platform will contain the most comprehensive cardiovascular data catalogue ever assembled, which will facilitate data discoverability and exploitation in full alignment with the...

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormalloading conditions. There are four major classifications of cardiomyopathy:

• hypertrophic (HCM),
• dilated...

Rare Diseases, Biobanks, Clinical BioinformaticsDespite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust...