Projects

The evolution of protein interactions has produced interaction networks and much biological complexity. Although molecular phylogenetics reveals the end points of evolutionary searches, little is known about the trajectories of interacting proteins through sequence space over evolutionary time. A major bottleneck is the inability to extensively map how binding affinity...

There is a continued need for higher compute performance: scientific grand challenges, engineering, geophysics, bioinformatics, etc. However, energy is increasingly becoming one of the most expensive resources and the dominant cost item for running a large supercomputing facility. In fact the total energy cost of a few years of operation can almost equal the cost of the...

Food and energy security are major challenges facing humanity in the coming decades. The falling costs of nucleotide sequencing are opening up significant opportunities for crop improvement through plant breeding and increased understanding of plant biology; in particular through interpreting the growing volume of plant genomics data in the context of phenotype. However, at...

Life Science developed into one of the largest e-Infrastructure users in Europe, in part due to the ever-growing amount of biological data. At the time of the project, modern drug design typically included both sequence bioinformatics, in silico virtual screening, and free energy calculations, e.g. of drug binding. This development has accelerated tremendously, and has put...

Several research communities in Europe exploit e-Infrastructures, sharing data and computing resources with Grid and Supercomputing technology. However the inherent complexity of these technologies has limited their wider adoption and their long term sustainability: designing, developing and operating a computing infrastructure for an e-Science community remains challenging...