Projects

Showing 101 - 110 results of 418

Modeling the heartbeat is a highly complex task that involves several scales and different tightly coupled problems. A large number of spatial orders of magnitude are linked, from the microscopic cell arrangement into a volumetric description, to the macroscopic shape of the cardiac chambers. In the same way, several temporal scales coexist, from...

Due to technological advances in experimental biology, we now have an astounding amount of various molecular and clinical data describing different aspects of the functioning of the cells. These complex big data carry biomedical information that is currently hidden from us within their large sizes and complexities. Hence, some of the foremost computational challenges that the...

Over the last decade we have made significant progress in understanding the role of genetics in cancer predisposition, evolution andtreatment. We now have thousands of germline variants associated with different types of cancer and we have also identified a fewhundred genes that, when somatically mutated, drive the growth of cancer cells.However, there are also many open...

Air quality modelling, urban mobility actions, multi-scale, health impact Air pollution continues to be one of the main issues in urban areas. In the particular case of Barcelona (Spain), chronic NO2 and PM2.5 exceedances are still recorded in urban traffic stations, highlighting the contribution of the road transport sector to population exposure to ambient concentrations....

Mesopelagic ocean, biogeochemistry, climate, carbon, plankton, particles, respiration, advection, model, Argo The mesopelagic layer of the oceans, also known as the Twilight Zone, extends between ~200 and 1000 m depth and is one of the vastest contiguous ecosystems on Earth. It plays a pivotal role in global biogeochemical cycles and climate, and hosts a massive biomass of...

In this project, we present PluriZymes, enzymes containing multiple (engineered) catalytic actives sites in a single scaffold, as one of the next breakthroughs in enzymatic catalysis. We show clear preliminary evidence of the potential role of PluriZymes in optimizing complex biochemical processes, such as cellulose degradation, or to group cascade reactions into one single...

Gene expression determines the identity of cells and it thus governs the process by which organs and tissues are formed and organized in an individual. Furthermore, differences in gene expression between individuals are known to play a crucial role in determining disease risk. However, the mechanisms of how such differences in gene expression are associated with disease...

Digital twins, along with the Internet of Things and Edge computing , are expected to play a decisive role in the nextdecade s industrial markets (Industry 4.0) enabling dramatic improvements in complex systems design and operation.However, this technology has not been yet widely implemented, since it requires the collaboration of experts in multiple fieldsand costly...

Cholangiocarcinoma (CCA) is a rare type of cancer and the second most common hepatobiliary malignancy, accounting for 10 to 20% of primary liver cancers. In the recent years, different groups have published data on the molecular biology of CCA, describing a complex pathogenesis, involving various molecular pathways, some of them potential therapeutic targets, such as...

Es esencial diseñar antivirales capaces de inhibir, a la vez, diversos coronaviruses, introduciendo así una serie de moléculas que puedan actuar como primera línea de choque en mutaciones de SARS-CoV-2 y en las pandemia venideras. Para ello, es imprescindible localizar dianas con alta similitud, bien caracterizadas estructuralmente, y realizar un...

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