BSC co-organizes the event and has proposed a challenge on the interaction of proteins involved in these diseases.
This year Bitsxlamarató is organized by the Barcelona Supercomputing Center (BSC) Faculty of Computer Science of Barcelona (FIB), Hackers@UPC, LleidaHack, and the Escola Superior d'Infemeria del Mar (Hospital del Mar) that come together to improve the quality of life of people affected by mental health.
After two editions, we join forces to help in the prevention and early treatment that are essential to achieve a positive evolution. This is a hackathon full of creativity, health and technology, where teachers, research staff and any professional in the fields of health and technology (but also other areas!), will work as a team for 3 days (face-to-face and online!). Together, they will look for and develop solutions to meet all the challenges that mental health poses to us, because one in four people will have a mental health problem throughout their life.
The hackathon will take place on December 10-12 and will include training talks. Participants who request it, will be able to use the MareNostrum supercomputer.
On the first day, the organizers will pose to the participants a series of challenges in which they can be of help. During the next two days, the participants, organized into teams, will try to make their contributions to respond to these challenges. During the last day of the hackathon, the teams will make presentations and demonstrations of the solutions and solution proposals obtained to the challenges posed on the first day. There will be a prize for the best project of each challenge.
Challenge on the interaction of proteins involved in these diseases.
The challenge proposed by BSC together with Nostrum BioDiscovery is called “Protein interaction. Do we agree?".
The relationship between some of the protein-protein interactions (PPIs) involved in mental health diseases has been established. However, most of these interactions do not have an experimental structure of the complex formed by the two interacting proteins, thus limiting the study of PPIs. For this reason, programs for modeling the docking between these proteins are necessary. However, these programs are not (in general) able to sort the different structures obtained by relevance by relevance. In addition, the metrics used by programs to rank the best and worst predictions are not comparable.
In this context, this challenge aims to obtain analysis algorithms in order to make a consensus between the different computer modeling programs of protein-protein docking at the structural level.