MARKERS OF PREDICTION OF RESPONSE TO CAR T CELL THERAPY

 Status:
Granted
 Publication number:
MARKERS OF PREDICTION OF RESPONSE TO CAR T CELL THERAPY
 Priority date:
 Inventor:
Carlos Antonio Garcia Prieto
 Applicant:
FUNDACIÓ INSTITUT DE RECERCA CONTRA LA LEUCÈMIA JOSEP CARRERAS, BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACIÓN, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Abstract

This invention relates to in vitro methods for predicting the response of a subject to autologous chimeric antigen receptor T-cell (CAR T-cell) therapy, the methods comprising determining the methylation status of one or more cytosines in CpG sites of CAR T-cells. There are also disclosed means and kits for carrying out the methods. With the determination of the methylation status of the one or more cytosines in CpG sites, a complete response free of events and long overall survival can be predicted as an outcome of the CAR T-cell therapy, in particular to subjects with B-cell malignancies.