Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors.
Authors: Castaño, Tania / Wang, Huanchen / Campillo, Nuria / Ballester, Sara / González-García, Coral / Hernández, Javier / Pérez, Concepción / Cuenca, Jimena / Pérez-Castillo, Ana / Martínez, Ana / Huertas, Oscar / Gelpí, Josep Lluís / Luque, Francisco Javier / Ke, Hengming / Gil, Carmen
Publication: ChemMedChem
Volume / Pagination: 4 / 866-76
Paraules clau: Animals, Anti-Inflammatory Agents, Catalytic Domain, Cells, Cultured, Crystallography, X-Ray, Cyclic AMP, Cyclic Nucleotide Phosphodiesterases, Type 4, Cyclic Nucleotide Phosphodiesterases, Type 7, Drug Design, Humans, Mice, Phosphodiesterase 4 Inhibitors, Phosphodiesterase Inhibitors, Quinazolines, Structure-Activity Relationship