Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5.
Authors: Lucas, MarÃa / Gaspar, Andrew / Pallara, Chiara / Rojas, Adriana / Fernandez-Recio, Juan / Machner, Matthias / Hierro, Aitor
Publication: Proc Natl Acad Sci U S A
Volume / Pagination: 111 / E3514-23
Paraules clau: Amino Acid Sequence, Amino Acid Substitution, Bacterial Proteins, Binding, Competitive, Catalytic Domain, Crystallography, X-Ray, Endosomes, Host-Pathogen Interactions, Humans, Legionella pneumophila, Models, Molecular, Molecular Dynamics Simulation, Molecular Sequence Data, Multiprotein Complexes, Mutagenesis, Site-Directed, Phospholipases A1, Protein Conformation, Protein Interaction Domains and Motifs, Protein Structure, Quaternary, rab5 GTP-Binding Proteins, Recombinant Proteins, Sequence Homology, Amino Acid, Vesicular Transport Proteins