Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides.
Authors: Terrazas, Montserrat / Alagia, Adele / Faustino, Ignacio / Orozco, Modesto / Eritja, Ramon
Publication: Chembiochem : a European journal of chemical biology
Volume / Pagination: 14 / 510-20
Paraules clau: 3' Flanking Region, Base Sequence, Cell Line, DNA, DNA Polymerase I, Exonucleases, Humans, Luciferases, Renilla, Molecular Dynamics Simulation, Nucleosides, Oligonucleotides, Proto-Oncogene Proteins c-bcl-2, RNA Interference, RNA, Small Interfering, Serum