Marta Mele

The Transcriptomics and Functional Genomics Lab led by Marta Melé is interested in understanding how the information encoded in our genome determines gene expression and splicing variation across individuals and tissues. To address this, we use a combination of cutting-edge computational analyses, next generation sequencing, and high-throughput functional...

Available single cell reference biological data of tissues from pediatric healthy individuals within collaborative projects as the Human Cell Atlas are scarce. This type of data is fundamental to determine how tissues develop throughout early stages of life and are projected to adulthood. Thus, it is necessary to generate pediatric specific data from diverse tissues that can...

Gene expression determines the identity of cells and it thus governs the process by which organs and tissues are formed and organized in an individual. Furthermore, differences in gene expression between individuals are known to play a crucial role in determining disease risk. However, the mechanisms of how such differences in gene expression are associated with disease...

Cholangiocarcinoma (CCA) is a rare type of cancer and the second most common hepatobiliary malignancy, accounting for 10 to 20% of primary liver cancers. In the recent years, different groups have published data on the molecular biology of CCA, describing a complex pathogenesis, involving various molecular pathways, some of them potential therapeutic targets, such as...