Computational Biology

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Mostrant 1 - 30 resultats de 171

2024

Frustraevo: a web server to localize and quantify the conservation of local energetic frustration in protein familiesAbstract

Nucleic Acids Research

G. R. Parra, M. I. Freiberger, M. Poley-Gil, M. Fernandez-Martin, L. G. Radusky, V. Ruiz-Serra, P. G. Wolynes, D. U. Ferreiro, and A. Valencia
Rare disease research workflow using multilayer networks elucidates the molecular determinants of severity in Congenital Myasthenic Syndromes

Nature Communications

I. Núñez-Carpintero, M. Rigau, M. Bosio, E. O'Connor, S. Spendiff, Y. Azuma, A. Topf, R. Thompson, T. Chamova, I. Tournev, V. Guergueltcheva, S. Laurie, S. Beltran, S. Capella-Gutierrez, D. Cirillo, H. Lochmüller, and A. Valencia

2023

Local energetic frustration conservation in protein families and superfamilies

Nature Communications

M. I. Freiberger, V. Ruiz-Serra, C. Pontes, M. Romero-Durana, P. Galaz-Davison, C. A. Ramírez-Sarmiento, C. D. Schuster, M. A. Marti, P. G. Wolynes, D. U. Ferreiro, G. R. Parra, and A. Valencia
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant

Frontiers in Immunology

C. Ávila-Nieto, J. Vergara-Alert, P. Amengual-Rigo, E. Ainsua-Enrich, M. Brustolin, M. Luisa Rodr de la Concepción, N. Pedreño-Lopez, J. Rodon, V. Urrea, E. Pradenas, S. Marfil, E. Ballana, E. Riveira-Muñoz, M. Pérez, N. Roca, F. Tarrés-Freixas, J. Carabelli, G. Cantero, A. Pons-Grífols, C. Rovirosa, C. Aguilar-Gurrieri, R. Ortiz, A. Barajas, B. Trinité, R. Lepore, J. Muñoz-Basagoiti, D. Perez-Zsolt, N. Izquierdo-Useros, A. Valencia, J. Blanco, B. Clotet, V. Guallar, J. Segalés, and J. Carrillo
The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer

Nature Communications

A. Armaos, F. Serra, I. Núñez-Carpintero, J-H. Seo, S. C. Baca, S. Gustincich, A. Valencia, M. L. Freedman, D. Cirillo, C. Giambartolomei, and G. Gaetano Tartaglia
PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks

npj Syst Biol Appl

M. Ponce-de-Leon, A. Montagud, V. Noël, A. Meert, G. Pradas, E. Barillot, L. Calzone, and A. Valencia
An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Journal of Visualized Experiments

L. Rovirosa, L. Tomas-Daza, B. Urmeneta, A. Valencia, and B. M. Javierre
Engaging European society at the forefront of cancer research and care

Molecular Oncology

M. Baumann, J. Celis, U. Ringborg, M. Heitor, A. Berns, T. Albreht, J. Arabadjiev, M. Boutros, M. Brandenburg, H. Canhao, F. Carneiro, C. Chomienne, F. De Lorenzo, A. M. M. Eggermont, A. Font, E. Garralda, M. Goulart, R. Henrique, M. Lawler, L. Maier‐Hein, F. Meunier, S. Oberst, P. Oliveira, M. Papatriantafyllou, J. Schüz, E. Solary, A. Valencia, R. Vargas, E. Weiderpass, and N. Wilking
Lessons Learned from a Performance Analysis and Optimization of a Multiscale Cellular Simulation

PASC '23: Platform for Advanced Scientific Computing ConferenceProceedings of the Platform for Advanced Scientific Computing Conference

A. Huebl, C. Silvano, T. Robinson, M. Clascà, M. Garcia-Gasulla, A. Montagud, J. Carbonell Caballero, and A. Valencia
eTRANSAFE: data science to empower translational safety assessment

Nature Reviews Drug Discovery

F. Sanz, F. Pognan, T. Steger-Hartmann, C. Díaz, S. Asakura, A. Amberg, N. Bécourt-Lhote, N. Blomberg, N. Bosc, K. Briggs, F. Bringezu, C. Brulle-Wohlhueter, S. Brunak, R. Bueters, G. Callegaro, S. Capella-Gutierrez, E. Centeno, J. Corvi, M. T. D. Cronin, P. Drew, G. Duchateau-Nguyen, G. F. Ecker, S. Escher, E. Felix, M. Ferreiro, M. Frericks, L. I. Furlong, R. Geiger, C. George, M. Grandits, D. Ivanov-Draganov, J. Kilgour-Christie, T. Kiziloren, J. A. Kors, N. Koyama, A. Kreuchwig, A. R. Leach, M-A. Mayer, P. Monecke, W. Muster, C. Miyamoto Nakazawa, G. Nicholson, R. Parry, M. Pastor, J. Piñero, N. Oberhauser, J. Manuel Ramírez-Anguita, A. Rodrigo, A. Smajic, M. Schaefer, S. Schieferdecker, I. Soininen, E. Terricabras, P. Trairatphisan, S. C. Turner, A. Valencia, B. van de Water, J. L. van der Lei, E. M. van Mulligen, E. Vock, and D. Wilkinson
Molecular bases of comorbidities: present and future perspectives

Trends in Genetics

J. Sánchez-Valle, and A. Valencia
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution

Nature Communications

L. Tomas-Daza, L. Rovirosa, P. López-Martí, A. Nieto-Aliseda, F. Serra, A. Planas-Riverola, O. Molina, R. McDonald, C. Ghevaert, E. Cuatrecasas, D. Costa, M. Camós, C. Bueno, P. Menéndez, A. Valencia, and B. M. Javierre

2022

Resolving the fine structure in the energy landscapes of repeat proteinsAbstract

QRB Discovery

M. N. Sanches, G. R. Parra, R. G. Viegas, A. B. Oliveira, P. G. Wolynes, D. U. Ferreiro, and V. B. P. Leite
Parallel model exploration for tumor treatment simulations

Computational Intelligence

C. Akasiadis, M. Ponce‐de‐Leon, A. Montagud, E. Michelioudakis, A. Atsidakou, E. Alevizos, A. Artikis, A. Valencia, and G. Paliouras
A first update on mapping the human genetic architecture of COVID-19

Nature

G. A. Pathak, J. Karjalainen, C. Stevens, B. M. Neale, M. Daly, A. Ganna, S. J. Andrews, M. Kanai, M. Cordioli, R. Polimanti, et al.
Look-alike humans identified by facial recognition algorithms show genetic similarities

Cell Reports

R. S. Joshi, M. Rigau, C. A. García-Prieto, M. Castro de Moura, D. Piñeyro, S. Morán, V. Davalos, P. Carrión, M. Ferrando-Bernal, I. Olalde, C. Lalueza-Fox, A. Navarro, C. Fernández-Tena, D. Aspandi, F. M. Sukno, X. Binefa, A. Valencia, and M. Esteller
ECCB2022: the 21st European Conference on Computational Biology

Bioinformatics

S. Capella-Gutierrez, E. Alloza, L. Rubinat-Ripoll, A. Conesa, and A. Valencia
A structural biology community assessment of AlphaFold2 applications

Nature Structural & Molecular Biology

M. Akdel, D. E. V. Pires, E. Porta Pardo, J. Jänes, A. O. Zalevsky, B. Mészáros, P. Bryant, L. L. Good, R. A. Laskowski, G. Pozzati, A. Shenoy, W. Zhu, P. Kundrotas, V. Ruiz Serra, C. H. M. Rodrigues, A. S. Dunham, D. Burke, N. Borkakoti, S. Velankar, A. Frost, J. Basquin, K. Lindorff-Larsen, A. Bateman, A. V. Kajava, A. Valencia, S. Ovchinnikov, J. Durairaj, D. B. Ascher, J. M. Thornton, N. E. Davey, A. Stein, A. Elofsson, T. I. Croll, and P. Beltrao
3D chromatin connectivity underlies replication origin efficiency in mouse embryonic stem cells

Nucleic Acids Research

K. Jodkowska, V. Pancaldi, M. Rigau, R. Almeida, J. M. Fernández-Justel, O. Graña-Castro, S. Rodríguez-Acebes, M. Rubio-Camarillo, E. Carrillo-d Pau, D. Pisano, F. Al-Shahrour, A. Valencia, M. Gómez, and J. Méndez
Sex and gender bias in natural language processing

Elsevier Academic Press

D. Cirillo, H. Gonen, E. Santus, A. Valencia, M. R. Costa-jussà, and M. Villegas
Auditing the quality of datasets used in algorithmic decision-making systems

European Parliament. Directorate General for Parliamentary Research Services

I. de MiguelBeriain, P. Nicolás Jiménez, M. José Rementeria, D. Cirillo, A. Cortés, D. Saby, and G. Lazcoz Moratino
Optimizing Dosage-Specific Treatments in a Multi-Scale Model of a Tumor

Frontiers in Molecular Biosciences

M. Ponce-de-Leon, A. Montagud, C. Akasiadis, J. Schreiber, T. Ntiniakou, and A. Valencia
Design and methodological characteristics of studies using observational routinely collected health data for investigating the link between cancer and neurodegenerative diseases: Protocol for a meta-research study

BMJ Open

F. Catalá-López, J. A. Driver, M. J. Page, B. Hutton, M. Ridao, C. Berrozpe-Villabona, A. Alonso-Arroyo, C. A. Fraga-Medín, E. Bernal-Delgado, A. Valencia, and R. Tabarés-Seisdedos
Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice

Frontiers in Microbiology

F. Tarrés-Freixas, B. Trinité, A. Pons-Grífols, M. Romero-Durana, E. Riveira-Muñoz, C. Ávila-Nieto, M. Pérez, E. Garcia-Vidal, D. Perez-Zsolt, J. Muñoz-Basagoiti, D. Raïch-Regué, N. Izquierdo-Useros, C. Andrés, A. Antón, T. Pumarola, I. Blanco, M. Noguera-Julian, V. Guallar, R. Lepore, A. Valencia, V. Urrea, J. Vergara-Alert, B. Clotet, E. Ballana, J. Carrillo, J. Segalés, and J. Blanco
Evaluating the policy of closing bars and restaurants in Cataluña and its effects on mobility and COVID19 incidence

Scientific Reports

M. Smith, M. Ponce-de-Leon, and A. Valencia
Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder

JAMA Pediatrics

F. Catalá-López, B. Hutton, M. J. Page, J. A. Driver, M. Ridao, A. Alonso-Arroyo, A. Valencia, D. Macías Saint-Gerons, and R. Tabarés-Seisdedos
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection

Cell Reports Medicine

E. Pradenas, B. Trinité, V. Urrea, S. Marfil, F. Tarrés-Freixas, R. Ortiz, C. Rovirosa, J. Rodon, J. Vergara-Alert, and J. Segalés
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection

Cell Reports Medicine

E. Pradenas, B. Trinité, V. Urrea, S. Marfil, F. Tarrés-Freixas, R. Ortiz, C. Rovirosa, J. Rodon, J. Vergara-Alert, J. Segalés, V. Guallar, A. Valencia, N. Izquierdo-Useros, M. Noguera-Julian, J. Carrillo, R. Paredes, L. Mateu, A. Chamorro, R. Toledo, M. Massanella, B. Clotet, and J. Blanco
Detection of oncogenic and clinically actionable mutations in cancer genomes critically depends on variant calling tools

Bioinformatics

C. A. Garcia-Prieto, F. Martínez-Jiménez, A. Valencia, and E. Porta-Pardo
The structural coverage of the human proteome before and after AlphaFold

PLoS computational biology

E. Porta-Pardo, V. Ruiz-Serra, S. Valentini, and A. Valencia

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